Jugal Saharia

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Dr. Jugal Saharia received his Ph.D. from Southern Methodist University at Dallas in May 2022. His primary research interests include single-molecule studies using solid-state nanopores. He has also worked on nanoscale transport phenomena, soft nanoparticles and nanopore fabrication. Dr. Saharia has published a book chapter and authored several articles in peer reviewed journals.

Before joining UTPB, he was an Assistant Research Scientist at InanoBio Inc., a nano-biotechnology company working on the development of an advanced 3D nanopore-transistor device for fast and high-accuracy sequencing of the human genome. Dr. Saharia also worked as an Assistant Professor of Mechanical Engineering at Girijananda Chowdhury Institute of Management and Technology, Guwahati (India) before moving to the United States for his Ph.D.

Education

Ph.D., Mechanical Engineering, Southern Methodist University, Dallas, TX
M.Tech., Mechanical Engineering, The University of Kerala, India
B.Tech., Mechanical Engineering, Tezpur University, India

Research Interests

• Single molecule biophysics
• Nanoscale transport phenomena
• soft nano/bio-particles
• Point-of-care technologies

 Publications

Book Chapter

• Bandara, Y. M., Jugal Saharia, Min Jun Kim, Scott Renkes, and George Alexandrakis. "Experimental Approaches to Solid-State Nanopores." In Single Molecule Sensing Beyond Fluorescence, pp. 297-341. Springer, Cham, 2022.

Peer Reviewed Journal Publication

• J. Saharia, Y.M.N.D.Y. Bandara, and M.J. Kim, “Investigating protein translocation in the presence of an electrolyte concentration gradient across a solid-state nanopore,” Electrophoresis, Vol. 43, p. 785-792. 2022. doi:10.1002/elps.202100346.
• J. Saharia, Y.M.N.D.Y. Bandara, B.I. Karawdeniya, C. Hammond, G. Alexandrakis, and M.J. Kim, “Modulation of electrophoresis, electroosmosis and diffusion for electrical transport of proteins through a solid-state nanopore,” RSC Advances, Vol. 11, p. 24398, 2021.
• Y.M.N.D.Y. Bandara, J. Saharia, B.I. Karawdeniya, P. Kluth, and M.J. Kim, “Nanopore Data Analysis: Baseline Construction and Abrupt Change-Based Multilevel Fitting,” Anal. Chem., Vol. 93, p. 11710-11718, 2021.
• J. Saharia, Y.M.N.D.Y. Bandara, B.I. Karawdeniya, G. Alexandrakis, and M.J. Kim, “Assessment of 1/f noise associated with nanopores fabricated through chemically-tuned controlled dielectric breakdown,” Electrophoresis, Vol. 42, p. 899-909, 2021.
• Y.M.N.D.Y. Bandara, J. Saharia, B.I. Karawdeniya, J. Hagan, J. Dwyer, and M.J. Kim, “Beyond nanopore sizing: Improving solid-state single-molecule sensing performance, lifetime, and analyze scope for comics by targeting surface chemistry during fabrication,” Nanotechnology, Vol. 32, 335707, 2020.
• J. Saharia, Y.M.N.D.Y. Bandara, J.S. Lee, Q. Wang, M.-J. Kim, and M.J. Kim, “Fabrication of hexagonal boron nitride based 2-D nanopore sensor for the assessment of electro-chemical responsiveness of human serum transferrin protein,” Electrophoresis, Vol. 41, p.630-637, 2020.
• Y.M.N.D.Y. Bandara, J. Tang, J. Saharia, L.W. Rogowski, C.W. Ahn, and M.J. Kim, “Characterization of flagellar filaments and flagellin through optical microscopy and label-free nanopore responsiveness,” Anal. Chem., Vol. 91, p.13665-13674, 2019.
• J. Saharia, Y.M.N.D.Y. Bandara, G. Goyal, J.S. Lee, B. I. Karawdeniya, and M.J. Kim, “Molecular level profiling of human serum transferrin protein through assessment of nanopore-based electrical and chemical responsiveness,” ACS Nano, Vol. 13, p. 4246-4254, 2019.
• J.S. Lee, J. Saharia, Y.M.N.D.Y. Bandara, G. Goyal, A. Darvish, Q. Wang, M.J. Kim, and M.-J. Kim, “Stiffness measurement of nanosized liposomes using solid-state nanopore sensor with automated recapturing platform,” Electrophoresis, Vol. 40, p. 1337-1344, 2019.
• A. Darvish, J.S. Lee, B. Peng, J. Saharia, R.V.K. Sundaram, G. Goyal, Y.M.N.D.Y. Bandara, C.W. Ahn, J.S. Kim, P. Dutta, I. Chaiken, and M.J. Kim, “Mechanical Characterization on HIV-1 with a Solid-state Nanopore,” Electrophoresis, Vol. 40, p. 776-783, 2019.

Patent

• Y.M.N.D.Y. Bandara, B.I. Karawdeniya, Buddini I., J. Saharia, M.J. Kim, and J.R. Dwyer. “Ohmic   Nanopore Fabrication and Real-Time Cleaning.” Patent US2021325329A1, Oct 21, 2021.